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Saturday, May 5, 2012

Can Medications cause OLP?



Oral lichen planus (OLP) can affect up to about 4% people, mostly in middle-aged adults, with women being affected twice as much as males.

Several studies have suggested a possible relationship between OLP and daily intake of medicine.

OLP lesions presumed to be related to long-term drug intake are referred to as lichenoid drug reactions (LDR).

Additionally, it is very difficult to identify the drug associated to LDR based on the patient’s medical history.

The best way to find out is observation that the lesion remits with drug withdrawal and returns on taking it again.

Many types of drugs have been implicated as a causative factor for  lichenoid drug reactions, especially the non-steroidal antiinflammatory drugs. (NSAIDS)

In one study involving 75 patients with OLP, of whom 20 were taking NSAIDS, 7 had a complete resolution of their oral lesions after withdrawal of the drug.

Of these 7 patients, 2 produced a recurrence when later taking the offending drug.

The purpose of the following study was to investigate whether the daily systemic and/or topical medicine used by patients with OLP contributes to the development of their oral lesions.

See the full article here:
http://www.progruda.com/UserFiles/image/ImageBank/Lichen%20Planus.pdf

1 comment:

Anonymous said...

My OLP has been attributed to a TDaP vaccination in 2012.
It is part of a whole range of autoimmune problems I have acquired.
As from a week ago, I have had great relief from the symptoms by taking MSM powder. This is the longest I have been without any of the foul tastes or pain being present in my mouth.

Jack Russell
25 Feb 15



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