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Friday, October 17, 2008

Pimecrolimus AKA Elidel®

I came across an abstract today which I found interesting. The intro says:

"Erosive oral lichen planus (EOLP) is a T-cell mediated inflammatory disease leading to severe pain and impairment. As current therapies are of limited efficacy, application of calcineurin inhibitors is considered to be a potential option.

Objective: To investigate the efficacy of pimecrolimus cream 1% (Elidel®) compared with vehicle cream in the treatment of EOLP"

This is my understanding of the abstract. Essentially, this is a study where they took EOLP patients, divided them in half, gave one group the Elidel cream, and the other group a placebo for 30 days. The result was that seven out of ten patients who used the Elidel for 30 days had improvement. ("erosions cleared completely") They were followed up another 30 days later and they continued to be in the same condition, except for the three who didn't respond at first. Those three continued the Elidel and then had improvement

I found this next part really fascinating:

"Following termination of the therapy, sustained remission of EOLP was detected in 83% of patients demonstrating long-lasting effects of pimecrolimus treatment."

This is the name of the study, the authors and publication:

Pimecrolimus cream 1% in erosive oral lichen planus— a prospective randomized double-blind vehicle-controlled study

Authors:
Volz, T.; Caroli, U.; Lüdtke, H.1; Bräutigam, M.2; Kohler-Späth, H.; Röcken, M.; Biedermann, T.

Source:
British Journal of Dermatology,
Volume 159, Number 4,
October 2008 , pp. 936-941(6)

4 comments:

Rich said...

Oral Erosive Lichen Planus Treated With Efalizumab
http://archderm.ama-assn.org/cgi/reprint/142/6/680.pdf

"Elizabliss" said...

Thank you, Rich

Penny said...

Elizabliss, I suffer as you do with eolp. This pimecrolimus AKA elidel sounds good.

"Elizabliss" said...

Penny, Sorry to hear you have this too. Good luck if you the Elidel. I hope it works for you. Let me know if it does.



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